Trypanosoma cruzi Induces the PARP1/AP-1 Pathway for Upregulation of Metalloproteinases and Transforming Growth Factor β in Macrophages: Role in Cardiac Fibroblast Differentiation and Fibrosis in Chagas Disease

Chagas disease (CD), caused by Trypanosoma cruzi, is a degenerative heart condition. In the present study, we investigated the role of poly [ADP-ribose] polymerase 1/activator protein 1 (PARP1/AP-1) in upregulation of profibrotic macrophages (Mϕ) and subsequent development of cardiac fibrosis in CD....

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Detalles Bibliográficos
Autores principales: Choudhuri, Subhadip, Garg, Nisha Jain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667027/
https://www.ncbi.nlm.nih.gov/pubmed/33172999
http://dx.doi.org/10.1128/mBio.01853-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667027/
https://www.ncbi.nlm.nih.gov/pubmed/33172999
http://dx.doi.org/10.1128/mBio.01853-20

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