Plasmodium berghei K13 Mutations Mediate In Vivo Artemisinin Resistance That Is Reversed by Proteasome Inhibition

The recent emergence of Plasmodium falciparum parasite resistance to the first line antimalarial drug artemisinin is of particular concern. Artemisinin resistance is primarily driven by mutations in the P. falciparum K13 protein, which enhance survival of early ring-stage parasites treated with the...

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Detalles Bibliográficos
Autores principales: Simwela, Nelson V., Stokes, Barbara H., Aghabi, Dana, Bogyo, Matt, Fidock, David A., Waters, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667033/
https://www.ncbi.nlm.nih.gov/pubmed/33173001
http://dx.doi.org/10.1128/mBio.02312-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667033/
https://www.ncbi.nlm.nih.gov/pubmed/33173001
http://dx.doi.org/10.1128/mBio.02312-20

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