Neuronal megalin mediates synaptic plasticity—a novel mechanism underlying intellectual disabilities in megalin gene pathologies

Donnai-Barrow syndrome, a genetic disorder associated to LRP2 (low-density lipoprotein receptor 2/megalin) mutations, is characterized by unexplained neurological symptoms and intellectual deficits. Megalin is a multifunctional endocytic clearance cell-surface receptor, mostly described in epithelia...

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Detalles Bibliográficos
Autores principales: Gomes, João R, Lobo, Andrea, Nogueira, Renata, Terceiro, Ana F, Costelha, Susete, Lopes, Igor M, Magalhães, Ana, Summavielle, Teresa, Saraiva, Maria J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667529/
https://www.ncbi.nlm.nih.gov/pubmed/33225275
http://dx.doi.org/10.1093/braincomms/fcaa135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667529/
https://www.ncbi.nlm.nih.gov/pubmed/33225275
http://dx.doi.org/10.1093/braincomms/fcaa135

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