Cargando…

Neuronal megalin mediates synaptic plasticity—a novel mechanism underlying intellectual disabilities in megalin gene pathologies

Donnai-Barrow syndrome, a genetic disorder associated to LRP2 (low-density lipoprotein receptor 2/megalin) mutations, is characterized by unexplained neurological symptoms and intellectual deficits. Megalin is a multifunctional endocytic clearance cell-surface receptor, mostly described in epithelia...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gomes, João R, Lobo, Andrea, Nogueira, Renata, Terceiro, Ana F, Costelha, Susete, Lopes, Igor M, Magalhães, Ana, Summavielle, Teresa, Saraiva, Maria J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667529/ https://www.ncbi.nlm.nih.gov/pubmed/33225275 http://dx.doi.org/10.1093/braincomms/fcaa135

Ejemplares similares

Renal uptake of different radiolabelled peptides is mediated by megalin: SPECT and biodistribution studies in megalin-deficient mice
por: Vegt, Erik, et al.
Publicado: (2010)

Transthyretin provides trophic support via megalin by promoting neurite outgrowth and neuroprotection in cerebral ischemia
por: Gomes, J R, et al.
Publicado: (2016)

Megalin Orchestrates FcRn Endocytosis and Trafficking
por: Dahlke, Eileen, et al.
Publicado: (2022)

Correlation of prechemotherapy urinary megalin ectodomain (A-megalin) levels with the development of cisplatin-induced nephrotoxicity: a prospective observational study
por: Shoji, Satoshi, et al.
Publicado: (2019)

Obesity and neuroinflammatory phenotype in mice lacking endothelial megalin
por: Bartolome, Fernando, et al.
Publicado: (2017)

Lack of megalin expression in adult human terminal ileum suggests megalin‐independent cubilin/amnionless activity during vitamin B(12) absorption
por: Jensen, Louise L., et al.
Publicado: (2014)

Rapamycin treatment induces tubular proteinuria: role of megalin-mediated protein reabsorption
por: Peres, Rodrigo A. S., et al.
Publicado: (2023)

Metallothioneins and Megalin Expression Profiling in Premalignant and Malignant Oral Squamous Epithelial Lesions
por: Zulijani, Ana, et al.
Publicado: (2021)

Proximal Tubular Expression Patterns of Megalin and Cubilin in Proteinuric Nephropathies
por: Sun, Jia, et al.
Publicado: (2017)

Megalin-Mediated Trafficking of Mitochondrial Intracrines: Relevance to Signaling and Metabolism
por: Sheikh-Hamad, David, et al.
Publicado: (2021)

It is Good to Recycle: Bringing Megalin Back to the Membrane to Stop Proteinuria
por: Hall, Andrew M, et al.
Publicado: (2022)

Soluble Megalin is Reduced in Cerebrospinal Fluid Samples of Alzheimer’s Disease Patients
por: Spuch, Carlos, et al.
Publicado: (2015)

Significance of Urinary Full-Length Megalin in Patients with IgA Nephropathy
por: Seki, Takuto, et al.
Publicado: (2014)

Megalin/lipoprotein receptor-related protein 2 autoimmunity and kidney disease
por: Perez-Gomez, Maria V, et al.
Publicado: (2020)

Megalin: a Novel Determinant of Renin-Angiotensin System Activity in the Kidney?
por: Sun, Yuan, et al.
Publicado: (2020)

Chaperone-Mediated Autophagy Upregulation Rescues Megalin Expression and Localization in Cystinotic Proximal Tubule Cells
por: Zhang, Jinzhong, et al.
Publicado: (2019)

The Endocytic Receptor Megalin and its Associated Proteins in Proximal Tubule Epithelial Cells
por: De, Shankhajit, et al.
Publicado: (2014)

The fast-recycling receptor Megalin defines the apical recycling pathway of epithelial cells
por: Perez Bay, Andres E., et al.
Publicado: (2016)

Megalin dependent urinary cystatin C excretion in ischemic kidney injury in rats
por: Jensen, Danny, et al.
Publicado: (2017)

Angiotensin II Stimulation of DPP4 Activity Regulates Megalin in the Proximal Tubules
por: Aroor, Annayya, et al.
Publicado: (2016)

Megalin and Vitamin D Metabolism—Implications in Non-Renal Tissues and Kidney Disease
por: Khan, Sono S., et al.
Publicado: (2022)

Influenza virus decreases albumin uptake and megalin expression in alveolar epithelial cells
por: Alberro-Brage, Andrés, et al.
Publicado: (2023)

Significance of Urinary Full-Length and Ectodomain Forms of Megalin in Patients With Type 2 Diabetes
por: Ogasawara, Shinya, et al.
Publicado: (2012)

ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression
por: Shah, Mehul, et al.
Publicado: (2013)

First description of subglacial megalineations from the late Paleozoic ice age in southern Africa
por: Andrews, Graham D., et al.
Publicado: (2019)

Hepatocyte nuclear factor 4α regulates megalin expression in proximal tubular cells
por: Sasaki, Shota, et al.
Publicado: (2018)

Ectopic germinal center and megalin defect in primary Sjogren syndrome with renal Fanconi syndrome
por: Wang, Jing, et al.
Publicado: (2017)

Megalin, Proton Pump Inhibitors and the Renin–Angiotensin System in Healthy and Pre-Eclamptic Placentas
por: Sun, Yuan, et al.
Publicado: (2021)

LDLR, LRP1, and Megalin redundantly participate in the uptake of Clostridium novyi alpha-toxin
por: Zhou, Yao, et al.
Publicado: (2022)

Megalin, cubilin, and Dab2 drive endocytic flux in kidney proximal tubule cells
por: Rbaibi, Youssef, et al.
Publicado: (2023)

SARS-CoV-2 spike protein inhibits megalin-mediated albumin endocytosis in proximal tubule epithelial cells
por: Silva-Aguiar, Rodrigo P., et al.
Publicado: (2022)

Microalbuminuria in Type 1 Diabetes Is Associated With Enhanced Excretion of the Endocytic Multiligand Receptors Megalin and Cubilin
por: Thrailkill, Kathryn M., et al.
Publicado: (2009)

Expression and immunolocalisation of the endocytic receptors megalin and cubilin in the human yolk sac and placenta across gestation()
por: Burke, K.A., et al.
Publicado: (2013)

Circulating FABP4 is eliminated by the kidney via glomerular filtration followed by megalin-mediated reabsorption
por: Shrestha, Suman, et al.
Publicado: (2018)

Renal miR-148b is associated with megalin down-regulation in IgA nephropathy
por: Wen, Lu, et al.
Publicado: (2018)

Significance of urinary C-megalin excretion in vitamin D metabolism in pre-dialysis CKD patients
por: Toi, Norikazu, et al.
Publicado: (2019)

Clathrin and clathrin adaptor AP-1 control apical trafficking of megalin in the biosynthetic and recycling routes
por: Gravotta, Diego, et al.
Publicado: (2019)

Endothelial-specific deficiency of megalin in the brain protects mice against high-fat diet challenge
por: Bartolome, Fernando, et al.
Publicado: (2020)

Expression profiles of metallothionein-I/II and megalin/LRP-2 in uterine cervical squamous lesions
por: Jakovac, Hrvoje, et al.
Publicado: (2020)

Functional megalin is expressed in renal cysts in a mouse model of adult polycystic kidney disease
por: Nielsen, Marlene L, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_1t8fa9rnj910c4en1rl1squral