Cargando…

Novel Small Molecules against Two Binding Sites of Wnt2 Protein as potential Drug Candidates for Colorectal Cancer: A Structure Based Virtual Screening Approach

Wnts are the major ligands responsible for activating Wnt signaling pathway through binding to Frizzled proteins (Fzd) as the receptors. Among these ligands, Wnt2 plays the main role in the tumorigenesis of several human cancers especially colorectal cancer (CRC). Therefore, it can be considered as...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kalhor, Hourieh, Rahimi, Hamzeh, Akbari Eidgahi, Mohammad Reza, Teimoori-Toolabi, Ladan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Shaheed Beheshti University of Medical Sciences 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667561/ https://www.ncbi.nlm.nih.gov/pubmed/33224221 http://dx.doi.org/10.22037/ijpr.2019.15297.13037

Ejemplares similares

Multi-targeting of K-Ras domains and mutations by peptide and small molecule inhibitors
por: Poorebrahim, Mansour, et al.
Publicado: (2022)

Rational design of DKK3 structure-based small peptides as antagonists of Wnt signaling pathway and in silico evaluation of their efficiency
por: Poorebrahim, Mansour, et al.
Publicado: (2017)

Different compounds against Angiotensin-Converting Enzyme 2 (ACE2) receptor potentially containing the infectivity of SARS-CoV-2: an in silico study
por: Shahbazi, Behzad, et al.
Publicado: (2022)

Identification of Putative Drug Targets in Highly Resistant Gram-Negative Bacteria; and Drug Discovery Against Glycyl-tRNA Synthetase as a New Target
por: Fereshteh, Sepideh, et al.
Publicado: (2023)

Evaluation of an Albumin-Binding Domain Protein Fused to Recombinant Human IL-2 and Its Effects on the Bioactivity and Serum Half-Life of the Cytokine
por: Adabi, Elham, et al.
Publicado: (2017)

An Enterovirus-Like RNA Construct for Colon Cancer Suicide Gene Therapy
por: Rasekhian, Mahsa, et al.
Publicado: (2015)

MiR-548c-3p through suppressing Tyms and Abcg2 increases the sensitivity of colorectal cancer cells to 5-fluorouracil
por: Khalili, Elham, et al.
Publicado: (2023)

Cytotoxic effect of dual fluorescent-labeled oncolytic herpes simplex virus type 1 on mouse tumorigenic cell lines
por: Abdoli, Shahriyar, et al.
Publicado: (2019)

Construction of Various γ34.5 Deleted Fluorescent-Expressing Oncolytic herpes Simplex type 1 (oHSV) for Generation and Isolation of HSV-Based Vectors
por: Abdoli, Shahriyar, et al.
Publicado: (2017)

The chicken chorioallantoic membrane model for isolation of CRISPR/cas9-based HSV-1 mutant expressing tumor suppressor p53
por: Kelishadi, Mishar, et al.
Publicado: (2023)

Optimization of post-insertion method to conjugate Doxil with anti-CD133 monoclonal antibodies: Investigating the specific binding and cytotoxicity to colorectal cancer cells in vitro
por: Dadashi Noshahr, Karim, et al.
Publicado: (2020)

Construction of a Synthetically Engineered nirB Promoter for Expression of Recombinant Protein in Escherichia coli
por: Nasr, Reza, et al.
Publicado: (2014)

Gene Expression and Methylation Pattern in HRK Apoptotic Gene in Myelodysplastic Syndrome
por: Zaker, Farhad, et al.
Publicado: (2016)

A vector-based system for the differentiation of mouse embryonic stem cells toward germ-line cells
por: Ebrahimzadeh-Vesal, Reza, et al.
Publicado: (2014)

Promoter Methylation of Tumor Suppressors in Thyroid Carcinoma: A Systematic Review
por: Sheikholeslami, Sara, et al.
Publicado: (2021)

Binding-Site Assessment by Virtual Fragment Screening
por: Huang, Niu, et al.
Publicado: (2010)

Meta-analysis of promoter methylation in eight tumor-suppressor genes and its association with the risk of thyroid cancer
por: Khatami, Fatemeh, et al.
Publicado: (2017)

Aberrant Methylation-Mediated Suppression of APAF1 in Myelodysplastic Syndrome
por: Zaker, Farhad, et al.
Publicado: (2017)

The Epigenetic Modification of SLC5A8 in Papillary Thyroid Carcinoma and its Effects on Clinic-Pathological Features
por: Sheikholeslami, Sara, et al.
Publicado: (2022)

Frequency of VanA, VanB and VanH variants amongst vancomycin-resistant enterococci isolated from patients in central region of Iran
por: Rezvani, Jaafar, et al.
Publicado: (2016)

Consensus Virtual Screening Protocol Towards the Identification of Small Molecules Interacting with the Colchicine Binding Site of the Tubulin‐microtubule System
por: López‐López, Edgar, et al.
Publicado: (2022)

Anticonvulsant Effect of Cicer arietinum Seed in Animal Models of Epilepsy: Introduction of an Active Molecule with Novel Chemical Structure
por: Sardari, Soroush, et al.
Publicado: (2015)

SstI Polymorphism of the Apolipoprotein CIII Gene in Iranian Hyperlipidemic Patients: A Study in Semnan Province
por: Bandegi, Ahmad Reza, et al.
Publicado: (2011)

NOL4 is Downregulated and Hyper-Methylated in Papillary Thyroid Carcinoma Suggesting Its Role as a Tumor Suppressor Gene
por: Sheikholeslami, Sara, et al.
Publicado: (2020)

Evaluation of the Effect of Promoter Type on the Immunogenicity of the Live Recombinant Salmonella Vaccines Expressing Escherichia Coli Heat-labile Enterotoxins (LTB)
por: Mohit, Elham, et al.
Publicado: (2018)

Identification of Candida Species Using MP65 Gene and Evaluation of the Candida albicans MP65 Gene Expression in BALB/C Mice
por: Bineshian, Farahnaz, et al.
Publicado: (2015)

Epinecidin-1, a highly potent marine antimicrobial peptide with anticancer and immunomodulatory activities
por: Neshani, Alireza, et al.
Publicado: (2019)

Correlation between Virtual Screening Performance and Binding Site Descriptors of Protein Targets
por: Shamsara, Jamal
Publicado: (2018)

Identification of binding sites and favorable ligand binding moieties by virtual screening and self-organizing map analysis
por: Harigua-Souiai, Emna, et al.
Publicado: (2015)

Expression Profile and Prognostic Value of Wnt Signaling Pathway Molecules in Colorectal Cancer
por: Wu, Yung-Fu, et al.
Publicado: (2021)

Drugsniffer: An Open Source Workflow for Virtually Screening Billions of Molecules for Binding Affinity to Protein Targets
por: Venkatraman, Vishwesh, et al.
Publicado: (2022)

Evaluation of a novel virtual screening strategy using receptor decoy binding sites
por: Patel, Hershna, et al.
Publicado: (2016)

Identification of Candidate Transcription Factor Binding Sites in the Cattle Genome
por: Bickhart, Derek M., et al.
Publicado: (2013)

Allosteric binding sites in Rab11 for potential drug candidates
por: Kumar, Ammu Prasanna, et al.
Publicado: (2018)

Virtual Screening and Binding Analysis of Potential CD58 Inhibitors in Colorectal Cancer (CRC)
por: Guo, Rong, et al.
Publicado: (2023)

Domain-based small molecule binding site annotation
por: Snyder, Kevin A, et al.
Publicado: (2006)

Knowledge and Attitudes of a Number of Iranian Policy-makers towards Abortion
por: Shamshiri-Milani, Hourieh, et al.
Publicado: (2010)

Virtual Screening for RNA-Interacting Small Molecules
por: Park, Hyun-Ju, et al.
Publicado: (2012)

How does a small molecule bind at a cryptic binding site?
por: Shan, Yibing, et al.
Publicado: (2022)

The incidence of candidate binding sites for β-arrestin in Drosophila neuropeptide GPCRs
por: Taghert, Paul H.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ed93o7flq5m648ljvl4h9klkjf