Optimized Opioid-Neurotensin Multitarget Peptides: From Design to Structure–Activity Relationship Studies

[Image: see text] Fusion of nonopioid pharmacophores, such as neurotensin, with opioid ligands represents an attractive approach for pain treatment. Herein, the μ-/δ-opioid agonist tetrapeptide H-Dmt-d-Arg-Aba-β-Ala-NH(2) (KGOP01) was fused to NT(8-13) analogues. Since the NTS1 receptor has been lin...

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Detalles Bibliográficos
Autores principales: Gonzalez, Simon, Dumitrascuta, Maria, Eiselt, Emilie, Louis, Stevany, Kunze, Linda, Blasiol, Annalisa, Vivancos, Mélanie, Previti, Santo, Dewolf, Elke, Martin, Charlotte, Tourwé, Dirk, Cavelier, Florine, Gendron, Louis, Sarret, Philippe, Spetea, Mariana, Ballet, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667639/
https://www.ncbi.nlm.nih.gov/pubmed/32902268
http://dx.doi.org/10.1021/acs.jmedchem.0c01376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667639/
https://www.ncbi.nlm.nih.gov/pubmed/32902268
http://dx.doi.org/10.1021/acs.jmedchem.0c01376

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