The Compelling Demand for an Effective PrP(C)-Directed Therapy against Prion Diseases

[Image: see text] Decades of research efforts have conclusively provided overwhelming evidence that the cellular prion protein (PrP(C)) plays a central role in prion diseases, a set of fatal and incurable neurodegenerative disorders for which no therapy is yet available. In this Viewpoint, we provid...

Descripción completa

Detalles Bibliográficos
Autores principales: Astolfi, Andrea, Spagnolli, Giovanni, Biasini, Emiliano, Barreca, Maria Letizia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667650/
https://www.ncbi.nlm.nih.gov/pubmed/33209189
http://dx.doi.org/10.1021/acsmedchemlett.0c00528
_version_ 1783610355255083008
author Astolfi, Andrea
Spagnolli, Giovanni
Biasini, Emiliano
Barreca, Maria Letizia
author_facet Astolfi, Andrea
Spagnolli, Giovanni
Biasini, Emiliano
Barreca, Maria Letizia
author_sort Astolfi, Andrea
collection PubMed
description [Image: see text] Decades of research efforts have conclusively provided overwhelming evidence that the cellular prion protein (PrP(C)) plays a central role in prion diseases, a set of fatal and incurable neurodegenerative disorders for which no therapy is yet available. In this Viewpoint, we provide an overview of the drug discovery strategies in the field, highlighting the current therapeutic hypotheses targeting, whether directly or indirectly, PrP(C) as well as the antiprion agents closest to clinical application.
format Online
Article
Text
id pubmed-7667650
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-76676502020-11-17 The Compelling Demand for an Effective PrP(C)-Directed Therapy against Prion Diseases Astolfi, Andrea Spagnolli, Giovanni Biasini, Emiliano Barreca, Maria Letizia ACS Med Chem Lett [Image: see text] Decades of research efforts have conclusively provided overwhelming evidence that the cellular prion protein (PrP(C)) plays a central role in prion diseases, a set of fatal and incurable neurodegenerative disorders for which no therapy is yet available. In this Viewpoint, we provide an overview of the drug discovery strategies in the field, highlighting the current therapeutic hypotheses targeting, whether directly or indirectly, PrP(C) as well as the antiprion agents closest to clinical application. American Chemical Society 2020-11-02 /pmc/articles/PMC7667650/ /pubmed/33209189 http://dx.doi.org/10.1021/acsmedchemlett.0c00528 Text en © 2020 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
spellingShingle Astolfi, Andrea
Spagnolli, Giovanni
Biasini, Emiliano
Barreca, Maria Letizia
The Compelling Demand for an Effective PrP(C)-Directed Therapy against Prion Diseases
title The Compelling Demand for an Effective PrP(C)-Directed Therapy against Prion Diseases
title_full The Compelling Demand for an Effective PrP(C)-Directed Therapy against Prion Diseases
title_fullStr The Compelling Demand for an Effective PrP(C)-Directed Therapy against Prion Diseases
title_full_unstemmed The Compelling Demand for an Effective PrP(C)-Directed Therapy against Prion Diseases
title_short The Compelling Demand for an Effective PrP(C)-Directed Therapy against Prion Diseases
title_sort compelling demand for an effective prp(c)-directed therapy against prion diseases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667650/
https://www.ncbi.nlm.nih.gov/pubmed/33209189
http://dx.doi.org/10.1021/acsmedchemlett.0c00528
work_keys_str_mv AT astolfiandrea thecompellingdemandforaneffectiveprpcdirectedtherapyagainstpriondiseases
AT spagnolligiovanni thecompellingdemandforaneffectiveprpcdirectedtherapyagainstpriondiseases
AT biasiniemiliano thecompellingdemandforaneffectiveprpcdirectedtherapyagainstpriondiseases
AT barrecamarialetizia thecompellingdemandforaneffectiveprpcdirectedtherapyagainstpriondiseases
AT astolfiandrea compellingdemandforaneffectiveprpcdirectedtherapyagainstpriondiseases
AT spagnolligiovanni compellingdemandforaneffectiveprpcdirectedtherapyagainstpriondiseases
AT biasiniemiliano compellingdemandforaneffectiveprpcdirectedtherapyagainstpriondiseases
AT barrecamarialetizia compellingdemandforaneffectiveprpcdirectedtherapyagainstpriondiseases

Ejemplares similares