A DNA methylation state transition model reveals the programmed epigenetic heterogeneity in human pre-implantation embryos

BACKGROUND: During mammalian early embryogenesis, expression and epigenetic heterogeneity emerge before the first cell fate determination, but the programs causing such determinate heterogeneity are largely unexplored. RESULTS: Here, we present MethylTransition, a novel DNA methylation state transit...

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Detalles Bibliográficos
Autores principales: Zhao, Chengchen, Zhang, Naiqian, Zhang, Yalin, Tuersunjiang, Nuermaimaiti, Gao, Shaorong, Liu, Wenqiang, Zhang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667739/
https://www.ncbi.nlm.nih.gov/pubmed/33198783
http://dx.doi.org/10.1186/s13059-020-02189-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667739/
https://www.ncbi.nlm.nih.gov/pubmed/33198783
http://dx.doi.org/10.1186/s13059-020-02189-8

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