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A DNA methylation state transition model reveals the programmed epigenetic heterogeneity in human pre-implantation embryos

BACKGROUND: During mammalian early embryogenesis, expression and epigenetic heterogeneity emerge before the first cell fate determination, but the programs causing such determinate heterogeneity are largely unexplored. RESULTS: Here, we present MethylTransition, a novel DNA methylation state transit...

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Detalles Bibliográficos
Autores principales:	Zhao, Chengchen, Zhang, Naiqian, Zhang, Yalin, Tuersunjiang, Nuermaimaiti, Gao, Shaorong, Liu, Wenqiang, Zhang, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667739/ https://www.ncbi.nlm.nih.gov/pubmed/33198783 http://dx.doi.org/10.1186/s13059-020-02189-8

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