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Who with whom: functional coordination of E2 enzymes by RING E3 ligases during poly‐ubiquitylation

Protein modification with poly‐ubiquitin chains is a crucial process involved in a myriad of cellular pathways. Chain synthesis requires two steps: substrate modification with ubiquitin (priming) followed by repetitive ubiquitin‐to‐ubiquitin attachment (elongation). RING‐type E3 ligases catalyze bot...

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Detalles Bibliográficos
Autores principales: Lips, Christian, Ritterhoff, Tobias, Weber, Annika, Janowska, Maria K, Mustroph, Mandy, Sommer, Thomas, Klevit, Rachel E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667886/
https://www.ncbi.nlm.nih.gov/pubmed/33015833
http://dx.doi.org/10.15252/embj.2020104863