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Visualization of the HIV-1 Env glycan shield across scales

The dense array of N-linked glycans on the HIV-1 envelope glycoprotein (Env), known as the “glycan shield,” is a key determinant of immunogenicity, yet intrinsic heterogeneity confounds typical structure–function analysis. Here, we present an integrated approach of single-particle electron cryomicro...

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Detalles Bibliográficos
Autores principales: Berndsen, Zachary T., Chakraborty, Srirupa, Wang, Xiaoning, Cottrell, Christopher A., Torres, Jonathan L., Diedrich, Jolene K., López, Cesar A., Yates, John R., van Gils, Marit J., Paulson, James C., Gnanakaran, Sandrasegaram, Ward, Andrew B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668054/
https://www.ncbi.nlm.nih.gov/pubmed/33093196
http://dx.doi.org/10.1073/pnas.2000260117