The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR

The recent discovery of sensory (tastant and odorant) G protein-coupled receptors on the smooth muscle of human bronchi suggests unappreciated therapeutic targets in the management of obstructive lung diseases. Here we have characterized the effects of a wide range of volatile odorants on the contra...

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Detalles Bibliográficos
Autores principales: Huang, Jessie, Lam, Hong, Koziol-White, Cynthia, Limjunyawong, Nathachit, Kim, Donghwa, Kim, Nicholas, Karmacharya, Nikhil, Rajkumar, Premraj, Firer, Danielle, Dalesio, Nicholas M., Jude, Joseph, Kurten, Richard C., Pluznick, Jennifer L., Deshpande, Deepak A., Penn, Raymond B., Liggett, Stephen B., Panettieri, Reynold A., Dong, Xinzhong, An, Steven S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668088/
https://www.ncbi.nlm.nih.gov/pubmed/33097666
http://dx.doi.org/10.1073/pnas.2003111117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668088/
https://www.ncbi.nlm.nih.gov/pubmed/33097666
http://dx.doi.org/10.1073/pnas.2003111117

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