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SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic that is a serious global health problem. Evasion of IFN-mediated antiviral signaling is a common defense strategy that pathogenic viruses use to replicate a...

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Detalles Bibliográficos
Autores principales: Miorin, Lisa, Kehrer, Thomas, Sanchez-Aparicio, Maria Teresa, Zhang, Ke, Cohen, Phillip, Patel, Roosheel S., Cupic, Anastasija, Makio, Tadashi, Mei, Menghan, Moreno, Elena, Danziger, Oded, White, Kris M., Rathnasinghe, Raveen, Uccellini, Melissa, Gao, Shengyan, Aydillo, Teresa, Mena, Ignacio, Yin, Xin, Martin-Sancho, Laura, Krogan, Nevan J., Chanda, Sumit K., Schotsaert, Michael, Wozniak, Richard W., Ren, Yi, Rosenberg, Brad R., Fontoura, Beatriz M. A., García-Sastre, Adolfo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668094/
https://www.ncbi.nlm.nih.gov/pubmed/33097660
http://dx.doi.org/10.1073/pnas.2016650117