Abnormal morphology biases hematocrit distribution in tumor vasculature and contributes to heterogeneity in tissue oxygenation

Oxygen heterogeneity in solid tumors is recognized as a limiting factor for therapeutic efficacy. This heterogeneity arises from the abnormal vascular structure of the tumor, but the precise mechanisms linking abnormal structure and compromised oxygen transport are only partially understood. In this...

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Detalles Bibliográficos
Autores principales: Bernabeu, Miguel O., Köry, Jakub, Grogan, James A., Markelc, Bostjan, Beardo, Albert, d’Avezac, Mayeul, Enjalbert, Romain, Kaeppler, Jakob, Daly, Nicholas, Hetherington, James, Krüger, Timm, Maini, Philip K., Pitt-Francis, Joe M., Muschel, Ruth J., Alarcón, Tomás, Byrne, Helen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Physical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668105/
https://www.ncbi.nlm.nih.gov/pubmed/33109723
http://dx.doi.org/10.1073/pnas.2007770117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668105/
https://www.ncbi.nlm.nih.gov/pubmed/33109723
http://dx.doi.org/10.1073/pnas.2007770117

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