Wake-sleep cycles are severely disrupted by diseases affecting cytoplasmic homeostasis

The circadian clock is based on a transcriptional feedback loop with an essential time delay before feedback inhibition. Previous work has shown that PERIOD (PER) proteins generate circadian time cues through rhythmic nuclear accumulation of the inhibitor complex and subsequent interaction with the...

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Detalles Bibliográficos
Autores principales: Beesley, Stephen, Kim, Dae Wook, D’Alessandro, Matthew, Jin, Yuanhu, Lee, Kwangjun, Joo, Hyunjeong, Young, Yang, Tomko, Robert J., Faulkner, John, Gamsby, Joshua, Kim, Jae Kyoung, Lee, Choogon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668169/
https://www.ncbi.nlm.nih.gov/pubmed/33106420
http://dx.doi.org/10.1073/pnas.2003524117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668169/
https://www.ncbi.nlm.nih.gov/pubmed/33106420
http://dx.doi.org/10.1073/pnas.2003524117

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