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Folding heterogeneity in the essential human telomerase RNA three-way junction

Telomeres safeguard the genome by suppressing illicit DNA damage responses at chromosome termini. To compensate for incomplete DNA replication at telomeres, most continually dividing cells, including many cancers, express the telomerase ribonucleoprotein (RNP) complex. Telomerase maintains telomere...

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Detalles Bibliográficos
Autores principales: Palka, Christina, Forino, Nicholas M., Hentschel, Jendrik, Das, Rhiju, Stone, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668248/
https://www.ncbi.nlm.nih.gov/pubmed/32817241
http://dx.doi.org/10.1261/rna.077255.120