Human disease-associated single nucleotide polymorphism changes the orientation of DROSHA on pri-mir-146a

The Microprocessor complex of DROSHA and DGCR8 initiates the biosynthesis of microRNAs (miRNAs) by processing primary miRNAs (pri-miRNAs). The Microprocessor can be oriented on pri-miRNAs in opposite directions to generate productive and unproductive cleavages at their basal and apical junctions, re...

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Detalles Bibliográficos
Autores principales: Le, Cong Truc, Nguyen, Thuy Linh, Nguyen, Trung Duc, Nguyen, Tuan Anh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668254/
https://www.ncbi.nlm.nih.gov/pubmed/32994184
http://dx.doi.org/10.1261/rna.077487.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668254/
https://www.ncbi.nlm.nih.gov/pubmed/32994184
http://dx.doi.org/10.1261/rna.077487.120

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