Phosphodiester modifications in mRNA poly(A) tail prevent deadenylation without compromising protein expression

Chemical modifications enable preparation of mRNAs with augmented stability and translational activity. In this study, we explored how chemical modifications of 5′,3′-phosphodiester bonds in the mRNA body and poly(A) tail influence the biological properties of eukaryotic mRNA. To obtain modified and...

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Detalles Bibliográficos
Autores principales: Strzelecka, Dominika, Smietanski, Miroslaw, Sikorski, Pawel J., Warminski, Marcin, Kowalska, Joanna, Jemielity, Jacek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668260/
https://www.ncbi.nlm.nih.gov/pubmed/32820035
http://dx.doi.org/10.1261/rna.077099.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668260/
https://www.ncbi.nlm.nih.gov/pubmed/32820035
http://dx.doi.org/10.1261/rna.077099.120

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