Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II α over β

[Image: see text] We disclose a novel class of 6-amino-tetrahydroquinazoline derivatives that inhibit human topoisomerase II (topoII), a validated target of anticancer drugs. In contrast to topoII-targeted drugs currently in clinical use, these compounds do not act as topoII poisons that enhance enz...

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Detalles Bibliográficos
Autores principales: Ortega, Jose Antonio, Arencibia, Jose M., Minniti, Elirosa, Byl, Jo Ann W., Franco-Ulloa, Sebastian, Borgogno, Marco, Genna, Vito, Summa, Maria, Bertozzi, Sine Mandrup, Bertorelli, Rosalia, Armirotti, Andrea, Minarini, Anna, Sissi, Claudia, Osheroff, Neil, De Vivo, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668297/
https://www.ncbi.nlm.nih.gov/pubmed/33079544
http://dx.doi.org/10.1021/acs.jmedchem.0c00774

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668297/
https://www.ncbi.nlm.nih.gov/pubmed/33079544
http://dx.doi.org/10.1021/acs.jmedchem.0c00774

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