A native function for RAN translation and CGG repeats in regulating Fragile X protein synthesis

Repeat-associated non-AUG translation of expanded CGG repeats (CGG RAN) from the FMR1 5’ UTR produces toxic proteins that contribute to neurodegeneration in Fragile X-associated Tremor/Ataxia Syndrome (FXTAS). Here we describe how unexpanded CGG repeats and their translation play conserved roles in...

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Detalles Bibliográficos
Autores principales: Rodriguez, Caitlin M., Wright, Shannon E., Kearse, Michael G., Haenfler, Jill M., Flores, Brittany N., Liu, Yu, Ifrim, Marius F., Glineburg, Mary R., Krans, Amy, Jafar-Nejad, Paymaan, Sutton, Michael A., Bassell, Gary J., Parent, Jack M., Rigo, Frank, Barmada, Sami J., Todd, Peter K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668390/
https://www.ncbi.nlm.nih.gov/pubmed/32066985
http://dx.doi.org/10.1038/s41593-020-0590-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668390/
https://www.ncbi.nlm.nih.gov/pubmed/32066985
http://dx.doi.org/10.1038/s41593-020-0590-1

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