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A native function for RAN translation and CGG repeats in regulating Fragile X protein synthesis

Repeat-associated non-AUG translation of expanded CGG repeats (CGG RAN) from the FMR1 5’ UTR produces toxic proteins that contribute to neurodegeneration in Fragile X-associated Tremor/Ataxia Syndrome (FXTAS). Here we describe how unexpanded CGG repeats and their translation play conserved roles in...

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Detalles Bibliográficos
Autores principales:	Rodriguez, Caitlin M., Wright, Shannon E., Kearse, Michael G., Haenfler, Jill M., Flores, Brittany N., Liu, Yu, Ifrim, Marius F., Glineburg, Mary R., Krans, Amy, Jafar-Nejad, Paymaan, Sutton, Michael A., Bassell, Gary J., Parent, Jack M., Rigo, Frank, Barmada, Sami J., Todd, Peter K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668390/ https://www.ncbi.nlm.nih.gov/pubmed/32066985 http://dx.doi.org/10.1038/s41593-020-0590-1

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