A monoclonal antibody with broad specificity for the ligands of insulin B:9-23 reactive T cells prevents spontaneous type 1 diabetes in mice

Activation of T cells specific for insulin B chain amino acids 9 to 23 (B:9–23) is essential for the initiation of type 1 diabetes (T1D) in non-obese diabetic mice. We previously reported that peptide/MHC complexes containing optimized B:9–23 mimotopes can activate most insulin-reactive pathogenic T...

Descripción completa

Detalles Bibliográficos
Autores principales: Cepeda, Joseph Ray, Sekhar, Nitin S, Han, Junying, Xiong, Wei, Zhang, Ningyan, Yu, Liping, Dai, Shaodong, Davidson, Howard W., Kappler, John W., An, Zhiqiang, Zhang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668530/
https://www.ncbi.nlm.nih.gov/pubmed/33151102
http://dx.doi.org/10.1080/19420862.2020.1836714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668530/
https://www.ncbi.nlm.nih.gov/pubmed/33151102
http://dx.doi.org/10.1080/19420862.2020.1836714

Ejemplares similares