Doxycycline has distinct apicoplast-specific mechanisms of antimalarial activity

Doxycycline (DOX) is a key antimalarial drug thought to kill Plasmodium parasites by blocking protein translation in the essential apicoplast organelle. Clinical use is primarily limited to prophylaxis due to delayed second-cycle parasite death at 1–3 µM serum concentrations. DOX concentrations >...

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Detalles Bibliográficos
Autores principales: Okada, Megan, Guo, Ping, Nalder, Shai-anne, Sigala, Paul A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669263/
https://www.ncbi.nlm.nih.gov/pubmed/33135634
http://dx.doi.org/10.7554/eLife.60246

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669263/
https://www.ncbi.nlm.nih.gov/pubmed/33135634
http://dx.doi.org/10.7554/eLife.60246

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