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Doxycycline has distinct apicoplast-specific mechanisms of antimalarial activity

Doxycycline (DOX) is a key antimalarial drug thought to kill Plasmodium parasites by blocking protein translation in the essential apicoplast organelle. Clinical use is primarily limited to prophylaxis due to delayed second-cycle parasite death at 1–3 µM serum concentrations. DOX concentrations >...

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Detalles Bibliográficos
Autores principales:	Okada, Megan, Guo, Ping, Nalder, Shai-anne, Sigala, Paul A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Microbiology and Infectious Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669263/ https://www.ncbi.nlm.nih.gov/pubmed/33135634 http://dx.doi.org/10.7554/eLife.60246

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