Uncovering the basis of protein-protein interaction specificity with a combinatorially complete library

Protein-protein interaction specificity is often encoded at the primary sequence level. However, the contributions of individual residues to specificity are usually poorly understood and often obscured by mutational robustness, sequence degeneracy, and epistasis. Using bacterial toxin-antitoxin syst...

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Detalles Bibliográficos
Autores principales: Lite, Thuy-Lan V, Grant, Robert A, Nocedal, Isabel, Littlehale, Megan L, Guo, Monica S, Laub, Michael T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669267/
https://www.ncbi.nlm.nih.gov/pubmed/33107822
http://dx.doi.org/10.7554/eLife.60924

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669267/
https://www.ncbi.nlm.nih.gov/pubmed/33107822
http://dx.doi.org/10.7554/eLife.60924

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