Structural basis for tuning activity and membrane specificity of bacterial cytolysins

Cholesterol-dependent cytolysins (CDCs) are pore-forming proteins that serve as major virulence factors for pathogenic bacteria. They target eukaryotic cells using different mechanisms, but all require the presence of cholesterol to pierce lipid bilayers. How CDCs use cholesterol to selectively lyse...

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Detalles Bibliográficos
Autores principales: Shah, Nita R., Voisin, Tomas B., Parsons, Edward S., Boyd, Courtney M., Hoogenboom, Bart W., Bubeck, Doryen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669874/
https://www.ncbi.nlm.nih.gov/pubmed/33199689
http://dx.doi.org/10.1038/s41467-020-19482-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669874/
https://www.ncbi.nlm.nih.gov/pubmed/33199689
http://dx.doi.org/10.1038/s41467-020-19482-6

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