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Regulation of p53 by the 14-3-3 protein interaction network: new opportunities for drug discovery in cancer

Most cancers evolve to disable the p53 pathway, a key tumour suppressor mechanism that prevents transformation and malignant cell growth. However, only ~50% exhibit inactivating mutations of p53, while in the rest its activity is suppressed by changes in the proteins that modulate the pathway. There...

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Detalles Bibliográficos
Autores principales: Falcicchio, Marta, Ward, Jake A., Macip, Salvador, Doveston, Richard G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669891/
https://www.ncbi.nlm.nih.gov/pubmed/33298896
http://dx.doi.org/10.1038/s41420-020-00362-3