Montreal Cognitive Assessment as Screening Measure for Mild and Major Neurocognitive Disorder in a Chilean Population

BACKGROUND: The Montreal Cognitive Assessment (MoCA) is a sensitive screening instrument for mild neurocognitive disorder (mild NCD). However, cut-off scores and accuracy indices should be established using representative samples of the population. In this context, the aim of this study was to updat...

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Autores principales: Bello-Lepe, Sebastian, Alonso-Sánchez, María Francisca, Ortega, Alonso, Gaete, Marcelo, Veliz, Marcela, Lira, Juan, Perez Salas, Claudia Paz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670370/
https://www.ncbi.nlm.nih.gov/pubmed/33250917
http://dx.doi.org/10.1159/000506280
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author Bello-Lepe, Sebastian
Alonso-Sánchez, María Francisca
Ortega, Alonso
Gaete, Marcelo
Veliz, Marcela
Lira, Juan
Perez Salas, Claudia Paz
author_facet Bello-Lepe, Sebastian
Alonso-Sánchez, María Francisca
Ortega, Alonso
Gaete, Marcelo
Veliz, Marcela
Lira, Juan
Perez Salas, Claudia Paz
author_sort Bello-Lepe, Sebastian
collection PubMed
description BACKGROUND: The Montreal Cognitive Assessment (MoCA) is a sensitive screening instrument for mild neurocognitive disorder (mild NCD). However, cut-off scores and accuracy indices should be established using representative samples of the population. In this context, the aim of this study was to update the normative values, and diagnostic efficiency statistics of the MoCA to detect mild NCD in the Chilean population. METHODS: This study included 226 participants from the north, center, and south of the country, classified into 3 groups: healthy elderly (HE; n = 113), mild NCD (n = 65), and major neurocognitive disorder (major NCD; n = 48). RESULTS: The optimal cut-off score to discriminate mild NCD from HE participants was 20 points with a sensitivity of 82.8% and a specificity of 84.1%. The observed balance between sensitivity and specificity shows a good test performance either to confirm or discard a diagnosis. The cut-off between mild NCD and major NCD from HE participants was 19 points with 85.6% of sensitivity and 90.3% of specificity. CONCLUSION: Overall diagnostic accuracy can be considered as outstanding (AUC ≥0.904) when discriminating HE from both mild NCD and major NCD. These results showed that the MoCA is a suitable tool to identify mild NCD and major NCD.
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spelling pubmed-76703702020-11-27 Montreal Cognitive Assessment as Screening Measure for Mild and Major Neurocognitive Disorder in a Chilean Population Bello-Lepe, Sebastian Alonso-Sánchez, María Francisca Ortega, Alonso Gaete, Marcelo Veliz, Marcela Lira, Juan Perez Salas, Claudia Paz Dement Geriatr Cogn Dis Extra Research Article BACKGROUND: The Montreal Cognitive Assessment (MoCA) is a sensitive screening instrument for mild neurocognitive disorder (mild NCD). However, cut-off scores and accuracy indices should be established using representative samples of the population. In this context, the aim of this study was to update the normative values, and diagnostic efficiency statistics of the MoCA to detect mild NCD in the Chilean population. METHODS: This study included 226 participants from the north, center, and south of the country, classified into 3 groups: healthy elderly (HE; n = 113), mild NCD (n = 65), and major neurocognitive disorder (major NCD; n = 48). RESULTS: The optimal cut-off score to discriminate mild NCD from HE participants was 20 points with a sensitivity of 82.8% and a specificity of 84.1%. The observed balance between sensitivity and specificity shows a good test performance either to confirm or discard a diagnosis. The cut-off between mild NCD and major NCD from HE participants was 19 points with 85.6% of sensitivity and 90.3% of specificity. CONCLUSION: Overall diagnostic accuracy can be considered as outstanding (AUC ≥0.904) when discriminating HE from both mild NCD and major NCD. These results showed that the MoCA is a suitable tool to identify mild NCD and major NCD. S. Karger AG 2020-10-14 /pmc/articles/PMC7670370/ /pubmed/33250917 http://dx.doi.org/10.1159/000506280 Text en Copyright © 2020 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission.
spellingShingle Research Article
Bello-Lepe, Sebastian
Alonso-Sánchez, María Francisca
Ortega, Alonso
Gaete, Marcelo
Veliz, Marcela
Lira, Juan
Perez Salas, Claudia Paz
Montreal Cognitive Assessment as Screening Measure for Mild and Major Neurocognitive Disorder in a Chilean Population
title Montreal Cognitive Assessment as Screening Measure for Mild and Major Neurocognitive Disorder in a Chilean Population
title_full Montreal Cognitive Assessment as Screening Measure for Mild and Major Neurocognitive Disorder in a Chilean Population
title_fullStr Montreal Cognitive Assessment as Screening Measure for Mild and Major Neurocognitive Disorder in a Chilean Population
title_full_unstemmed Montreal Cognitive Assessment as Screening Measure for Mild and Major Neurocognitive Disorder in a Chilean Population
title_short Montreal Cognitive Assessment as Screening Measure for Mild and Major Neurocognitive Disorder in a Chilean Population
title_sort montreal cognitive assessment as screening measure for mild and major neurocognitive disorder in a chilean population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670370/
https://www.ncbi.nlm.nih.gov/pubmed/33250917
http://dx.doi.org/10.1159/000506280
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