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VADER: a variable dose-rate external (137)Cs irradiator for internal emitter and low dose rate studies
In the long term, (137)Cs is probably the most biologically important agent released in many accidental (or malicious) radiation disasters. It can enter the food chain, and be consumed, or, if present in the environment (e.g. from fallout), can provide external irradiation over prolonged times. In e...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670416/ https://www.ncbi.nlm.nih.gov/pubmed/33199728 http://dx.doi.org/10.1038/s41598-020-76941-2 |
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author | Garty, Guy Xu, Yanping Johnson, Gary W. Smilenov, Lubomir B. Joseph, Simon K. Pujol-Canadell, Monica Turner, Helen C. Ghandhi, Shanaz A. Wang, Qi Shih, Rompin Morton, Robert C. Cuniberti, David E. Morton, Shad R. Bueno-Beti, Carlos Morgan, Thomas L. Caracappa, Peter F. Laiakis, Evagelia C. Fornace, Albert J. Amundson, Sally A. Brenner, David J. |
author_facet | Garty, Guy Xu, Yanping Johnson, Gary W. Smilenov, Lubomir B. Joseph, Simon K. Pujol-Canadell, Monica Turner, Helen C. Ghandhi, Shanaz A. Wang, Qi Shih, Rompin Morton, Robert C. Cuniberti, David E. Morton, Shad R. Bueno-Beti, Carlos Morgan, Thomas L. Caracappa, Peter F. Laiakis, Evagelia C. Fornace, Albert J. Amundson, Sally A. Brenner, David J. |
author_sort | Garty, Guy |
collection | PubMed |
description | In the long term, (137)Cs is probably the most biologically important agent released in many accidental (or malicious) radiation disasters. It can enter the food chain, and be consumed, or, if present in the environment (e.g. from fallout), can provide external irradiation over prolonged times. In either case, due to the high penetration of the energetic γ rays emitted by (137)Cs, the individual will be exposed to a low dose rate, uniform, whole body, irradiation. The VADER (VAriable Dose-rate External (137)Cs irradiatoR) allows modeling these exposures, bypassing many of the problems inherent in internal emitter studies. Making use of discarded (137)Cs brachytherapy seeds, the VADER can provide varying low dose rate irradiations at dose rates of 0.1 to 1.2 Gy/day. The VADER includes a mouse “hotel”, designed to allow long term simultaneous residency of up to 15 mice. Two source platters containing ~ 250 mCi each of (137)Cs brachytherapy seeds are mounted above and below the “hotel” and can be moved under computer control to provide constant low dose rate or a varying dose rate mimicking (137)Cs biokinetics in mouse or man. We present the VADER design and characterization of its performance over 18 months of use. |
format | Online Article Text |
id | pubmed-7670416 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-76704162020-11-18 VADER: a variable dose-rate external (137)Cs irradiator for internal emitter and low dose rate studies Garty, Guy Xu, Yanping Johnson, Gary W. Smilenov, Lubomir B. Joseph, Simon K. Pujol-Canadell, Monica Turner, Helen C. Ghandhi, Shanaz A. Wang, Qi Shih, Rompin Morton, Robert C. Cuniberti, David E. Morton, Shad R. Bueno-Beti, Carlos Morgan, Thomas L. Caracappa, Peter F. Laiakis, Evagelia C. Fornace, Albert J. Amundson, Sally A. Brenner, David J. Sci Rep Article In the long term, (137)Cs is probably the most biologically important agent released in many accidental (or malicious) radiation disasters. It can enter the food chain, and be consumed, or, if present in the environment (e.g. from fallout), can provide external irradiation over prolonged times. In either case, due to the high penetration of the energetic γ rays emitted by (137)Cs, the individual will be exposed to a low dose rate, uniform, whole body, irradiation. The VADER (VAriable Dose-rate External (137)Cs irradiatoR) allows modeling these exposures, bypassing many of the problems inherent in internal emitter studies. Making use of discarded (137)Cs brachytherapy seeds, the VADER can provide varying low dose rate irradiations at dose rates of 0.1 to 1.2 Gy/day. The VADER includes a mouse “hotel”, designed to allow long term simultaneous residency of up to 15 mice. Two source platters containing ~ 250 mCi each of (137)Cs brachytherapy seeds are mounted above and below the “hotel” and can be moved under computer control to provide constant low dose rate or a varying dose rate mimicking (137)Cs biokinetics in mouse or man. We present the VADER design and characterization of its performance over 18 months of use. Nature Publishing Group UK 2020-11-16 /pmc/articles/PMC7670416/ /pubmed/33199728 http://dx.doi.org/10.1038/s41598-020-76941-2 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Garty, Guy Xu, Yanping Johnson, Gary W. Smilenov, Lubomir B. Joseph, Simon K. Pujol-Canadell, Monica Turner, Helen C. Ghandhi, Shanaz A. Wang, Qi Shih, Rompin Morton, Robert C. Cuniberti, David E. Morton, Shad R. Bueno-Beti, Carlos Morgan, Thomas L. Caracappa, Peter F. Laiakis, Evagelia C. Fornace, Albert J. Amundson, Sally A. Brenner, David J. VADER: a variable dose-rate external (137)Cs irradiator for internal emitter and low dose rate studies |
title | VADER: a variable dose-rate external (137)Cs irradiator for internal emitter and low dose rate studies |
title_full | VADER: a variable dose-rate external (137)Cs irradiator for internal emitter and low dose rate studies |
title_fullStr | VADER: a variable dose-rate external (137)Cs irradiator for internal emitter and low dose rate studies |
title_full_unstemmed | VADER: a variable dose-rate external (137)Cs irradiator for internal emitter and low dose rate studies |
title_short | VADER: a variable dose-rate external (137)Cs irradiator for internal emitter and low dose rate studies |
title_sort | vader: a variable dose-rate external (137)cs irradiator for internal emitter and low dose rate studies |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670416/ https://www.ncbi.nlm.nih.gov/pubmed/33199728 http://dx.doi.org/10.1038/s41598-020-76941-2 |
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