APOE4 genetic polymorphism results in impaired recovery in a repeated mild traumatic brain injury model and treatment with Bryostatin-1 improves outcomes

After traumatic brain injury (TBI), some people have worse recovery than others. Single nucleotide polymorphisms (SNPs) in Apolipoprotein E (APOE) are known to increase risk for developing Alzheimer’s disease, however there is controversy from human and rodent studies as to whether ApoE4 is a risk f...

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Detalles Bibliográficos
Autores principales: Giarratana, Anna O., Zheng, Cynthia, Reddi, Sahithi, Teng, Shavonne L., Berger, David, Adler, Derek, Sullivan, Patrick, Thakker-Varia, Smita, Alder, Janet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670450/
https://www.ncbi.nlm.nih.gov/pubmed/33199792
http://dx.doi.org/10.1038/s41598-020-76849-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670450/
https://www.ncbi.nlm.nih.gov/pubmed/33199792
http://dx.doi.org/10.1038/s41598-020-76849-x

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