Contextual experience modifies functional connectome indices of topological strength and efficiency

Stimuli presented at short temporal delays before functional magnetic resonance imaging (fMRI) can have a robust impact on the organization of synchronous activity in resting state networks. This presents an opportunity to investigate how sensory, affective and cognitive stimuli alter functional con...

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Autores principales: Pompilus, Marjory, Colon-Perez, Luis M., Grudny, Matteo M., Febo, Marcelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670469/
https://www.ncbi.nlm.nih.gov/pubmed/33199790
http://dx.doi.org/10.1038/s41598-020-76935-0
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author Pompilus, Marjory
Colon-Perez, Luis M.
Grudny, Matteo M.
Febo, Marcelo
author_facet Pompilus, Marjory
Colon-Perez, Luis M.
Grudny, Matteo M.
Febo, Marcelo
author_sort Pompilus, Marjory
collection PubMed
description Stimuli presented at short temporal delays before functional magnetic resonance imaging (fMRI) can have a robust impact on the organization of synchronous activity in resting state networks. This presents an opportunity to investigate how sensory, affective and cognitive stimuli alter functional connectivity in rodent models. In the present study we assessed the effect on functional connectivity of a familiar contextual stimulus presented 10 min prior to sedation for imaging. A subset of animals were co-presented with an unfamiliar social stimulus in the same environment to further investigate the effect of familiarity on network topology. Rats were imaged at 11.1 T and graph theory analysis was applied to matrices generated from seed-based functional connectivity data sets with 144 brain regions (nodes) and 10,152 pairwise correlations (after excluding 144 diagonal edges). Our results show substantial changes in network topology in response to the familiar (context). Presentation of the familiar context, both in the absence and presence of the social stimulus, strongly reduced network strength, global efficiency, and altered the location of the highest eigenvector centrality nodes from cortex to the hypothalamus. We did not observe changes in modular organization, nodal cartographic assignments, assortative mixing, rich club organization, and network resilience. We propose that experiential factors, perhaps involving associative or episodic memory, can exert a dramatic effect on functional network strength and efficiency when presented at a short temporal delay before imaging.
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spelling pubmed-76704692020-11-18 Contextual experience modifies functional connectome indices of topological strength and efficiency Pompilus, Marjory Colon-Perez, Luis M. Grudny, Matteo M. Febo, Marcelo Sci Rep Article Stimuli presented at short temporal delays before functional magnetic resonance imaging (fMRI) can have a robust impact on the organization of synchronous activity in resting state networks. This presents an opportunity to investigate how sensory, affective and cognitive stimuli alter functional connectivity in rodent models. In the present study we assessed the effect on functional connectivity of a familiar contextual stimulus presented 10 min prior to sedation for imaging. A subset of animals were co-presented with an unfamiliar social stimulus in the same environment to further investigate the effect of familiarity on network topology. Rats were imaged at 11.1 T and graph theory analysis was applied to matrices generated from seed-based functional connectivity data sets with 144 brain regions (nodes) and 10,152 pairwise correlations (after excluding 144 diagonal edges). Our results show substantial changes in network topology in response to the familiar (context). Presentation of the familiar context, both in the absence and presence of the social stimulus, strongly reduced network strength, global efficiency, and altered the location of the highest eigenvector centrality nodes from cortex to the hypothalamus. We did not observe changes in modular organization, nodal cartographic assignments, assortative mixing, rich club organization, and network resilience. We propose that experiential factors, perhaps involving associative or episodic memory, can exert a dramatic effect on functional network strength and efficiency when presented at a short temporal delay before imaging. Nature Publishing Group UK 2020-11-16 /pmc/articles/PMC7670469/ /pubmed/33199790 http://dx.doi.org/10.1038/s41598-020-76935-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Pompilus, Marjory
Colon-Perez, Luis M.
Grudny, Matteo M.
Febo, Marcelo
Contextual experience modifies functional connectome indices of topological strength and efficiency
title Contextual experience modifies functional connectome indices of topological strength and efficiency
title_full Contextual experience modifies functional connectome indices of topological strength and efficiency
title_fullStr Contextual experience modifies functional connectome indices of topological strength and efficiency
title_full_unstemmed Contextual experience modifies functional connectome indices of topological strength and efficiency
title_short Contextual experience modifies functional connectome indices of topological strength and efficiency
title_sort contextual experience modifies functional connectome indices of topological strength and efficiency
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670469/
https://www.ncbi.nlm.nih.gov/pubmed/33199790
http://dx.doi.org/10.1038/s41598-020-76935-0
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