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Recombinant Extracellular Domain (p75ECD) of the Neurotrophin Receptor p75 Attenuates Myocardial Ischemia–Reperfusion Injury by Inhibiting the p‐JNK/Caspase‐3 Signaling Pathway in Rat Microvascular Pericytes

BACKGROUND: Pro‐NTs (precursor of neurotrophins) and their receptor p75 are potential targets for preventing microvascular dysfunction induced by myocardial ischemia–reperfusion injury (IRI). p75ECD (ectodomain of neurotrophin receptor p75) may physiologically produce neurocytoprotective effects by...

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Detalles Bibliográficos
Autores principales: Fang, Jun, Wei, ZhiXiong, Zheng, DeDong, Ying, Teng, Hong, HuaShan, Hu, DanQing, Lin, YunLing, Jiang, XiaoLiang, Wu, LingZhen, Lan, TingXiang, Yang, ZhiWei, Zhou, XinFu, Chen, LiangLong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670530/
https://www.ncbi.nlm.nih.gov/pubmed/32567476
http://dx.doi.org/10.1161/JAHA.119.016047