Relationship Between Time‐Dependent Proteinuria and Risk of Stroke in Population With Different Glucose Tolerance Status
BACKGROUND: Proteinuria often changes and is known as a “time‐dependent exposure.” The effect of time‐dependent proteinuria on the risk of future stroke remains unclear. Proteinuria is often detected in patients with diabetes mellitus. The present study was designed to evaluate the association betwe...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670539/ https://www.ncbi.nlm.nih.gov/pubmed/32536236 http://dx.doi.org/10.1161/JAHA.120.015776 |
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author | Wang, Anxin Zhang, Jia Li, Jingjing Li, Haibin Zuo, Yingting Lv, Wei Chen, Shuohua Li, Junjuan Meng, Xia Wu, Shouling Zhao, Xingquan Wang, Yongjun |
author_facet | Wang, Anxin Zhang, Jia Li, Jingjing Li, Haibin Zuo, Yingting Lv, Wei Chen, Shuohua Li, Junjuan Meng, Xia Wu, Shouling Zhao, Xingquan Wang, Yongjun |
author_sort | Wang, Anxin |
collection | PubMed |
description | BACKGROUND: Proteinuria often changes and is known as a “time‐dependent exposure.” The effect of time‐dependent proteinuria on the risk of future stroke remains unclear. Proteinuria is often detected in patients with diabetes mellitus. The present study was designed to evaluate the association between time‐dependent proteinuria and the risk of stroke in a patient cohort with different glucose tolerance status. METHODS AND RESULTS: A total of 82 938 participants, who were free of myocardial infarction or stroke and underwent fasting blood glucose and urinary protein measurements at baseline in the Kailuan study, were enrolled. Proteinuria was determined using urine dipstick tests at baseline and subsequent follow‐ups. Time‐dependent proteinuria was defined as the status of urine protein updated through the follow‐up examinations, separately. Time‐dependent Cox regression models were used to analyze the relationship between time‐dependent proteinuria and the risk of stroke. During a median follow‐up of 8.37 years, 2538 participants developed stroke. After adjusting for confounding factors, the hazard ratio (95% CI) for stroke in time‐dependent proteinuria among all participants, and the normoglycemia, prediabetes, and diabetes mellitus populations were 1.68 (1.49–1.89), 1.73 (1.47–2.05), 2.15 (1.70–2.72), and 1.30 (1.03–1.65), respectively. There were interaction effects in patients with normoglycemia and prediabetes compared with those with diabetes mellitus. Findings were similar for ischemic and hemorrhagic strokes and were confirmed in sensitivity analyses. CONCLUSIONS: Time‐dependent proteinuria is an independent risk factor of stroke, especially in the normoglycemia and prediabetes populations. |
format | Online Article Text |
id | pubmed-7670539 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-76705392020-11-23 Relationship Between Time‐Dependent Proteinuria and Risk of Stroke in Population With Different Glucose Tolerance Status Wang, Anxin Zhang, Jia Li, Jingjing Li, Haibin Zuo, Yingting Lv, Wei Chen, Shuohua Li, Junjuan Meng, Xia Wu, Shouling Zhao, Xingquan Wang, Yongjun J Am Heart Assoc Original Research BACKGROUND: Proteinuria often changes and is known as a “time‐dependent exposure.” The effect of time‐dependent proteinuria on the risk of future stroke remains unclear. Proteinuria is often detected in patients with diabetes mellitus. The present study was designed to evaluate the association between time‐dependent proteinuria and the risk of stroke in a patient cohort with different glucose tolerance status. METHODS AND RESULTS: A total of 82 938 participants, who were free of myocardial infarction or stroke and underwent fasting blood glucose and urinary protein measurements at baseline in the Kailuan study, were enrolled. Proteinuria was determined using urine dipstick tests at baseline and subsequent follow‐ups. Time‐dependent proteinuria was defined as the status of urine protein updated through the follow‐up examinations, separately. Time‐dependent Cox regression models were used to analyze the relationship between time‐dependent proteinuria and the risk of stroke. During a median follow‐up of 8.37 years, 2538 participants developed stroke. After adjusting for confounding factors, the hazard ratio (95% CI) for stroke in time‐dependent proteinuria among all participants, and the normoglycemia, prediabetes, and diabetes mellitus populations were 1.68 (1.49–1.89), 1.73 (1.47–2.05), 2.15 (1.70–2.72), and 1.30 (1.03–1.65), respectively. There were interaction effects in patients with normoglycemia and prediabetes compared with those with diabetes mellitus. Findings were similar for ischemic and hemorrhagic strokes and were confirmed in sensitivity analyses. CONCLUSIONS: Time‐dependent proteinuria is an independent risk factor of stroke, especially in the normoglycemia and prediabetes populations. John Wiley and Sons Inc. 2020-06-13 /pmc/articles/PMC7670539/ /pubmed/32536236 http://dx.doi.org/10.1161/JAHA.120.015776 Text en © 2020 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Research Wang, Anxin Zhang, Jia Li, Jingjing Li, Haibin Zuo, Yingting Lv, Wei Chen, Shuohua Li, Junjuan Meng, Xia Wu, Shouling Zhao, Xingquan Wang, Yongjun Relationship Between Time‐Dependent Proteinuria and Risk of Stroke in Population With Different Glucose Tolerance Status |
title | Relationship Between Time‐Dependent Proteinuria and Risk of Stroke in Population With Different Glucose Tolerance Status |
title_full | Relationship Between Time‐Dependent Proteinuria and Risk of Stroke in Population With Different Glucose Tolerance Status |
title_fullStr | Relationship Between Time‐Dependent Proteinuria and Risk of Stroke in Population With Different Glucose Tolerance Status |
title_full_unstemmed | Relationship Between Time‐Dependent Proteinuria and Risk of Stroke in Population With Different Glucose Tolerance Status |
title_short | Relationship Between Time‐Dependent Proteinuria and Risk of Stroke in Population With Different Glucose Tolerance Status |
title_sort | relationship between time‐dependent proteinuria and risk of stroke in population with different glucose tolerance status |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670539/ https://www.ncbi.nlm.nih.gov/pubmed/32536236 http://dx.doi.org/10.1161/JAHA.120.015776 |
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