The effect of grape seed and green tea extracts on the pharmacokinetics of imatinib and its main metabolite, N-desmethyl imatinib, in rats

BACKGROUND: Imatinib is mainly metabolized by CYP3A4 and to a lesser extent by other isoenzymes, with N-desmethyl imatinib being its major equipotent metabolite. Being a CYP3A4 substrate, imatinib co-administration with CYP3A4 modulators would change its pharmacokinetic profile. The cancer chemoprev...

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Detalles Bibliográficos
Autores principales: Darweesh, Ruba S., El-Elimat, Tamam, Zayed, Aref, Khamis, Tareq N., Babaresh, Wahby M., Arafat, Tawfiq, Al Sharie, Ahmed H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670682/
https://www.ncbi.nlm.nih.gov/pubmed/33198812
http://dx.doi.org/10.1186/s40360-020-00456-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670682/
https://www.ncbi.nlm.nih.gov/pubmed/33198812
http://dx.doi.org/10.1186/s40360-020-00456-9

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