Substantia nigra Smad3 signaling deficiency: relevance to aging and Parkinson’s disease and roles of microglia, proinflammatory factors, and MAPK

BACKGROUND: Smad3 signaling is indicated to regulate microglia activity. Parkinson’s disease (PD) neurodegeneration is shown to be associated with aging and neuroinflammation. However, it remains unclear about the relationship among Smad3 signaling, aging, neuroinflammation, and PD. METHODS: Rats we...

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Detalles Bibliográficos
Autores principales: Liu, Ying, Yu, Lijia, Xu, Yaling, Tang, Xiaohui, Wang, Xijin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670688/
https://www.ncbi.nlm.nih.gov/pubmed/33198771
http://dx.doi.org/10.1186/s12974-020-02023-9

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