Development of a nano-luciferase based assay to measure the binding of SARS-CoV-2 spike receptor binding domain to ACE-2

To identify drugs that could potentially be used to treat infection with SARS-CoV-2, a high throughput 384-well assay was developed to measure the binding of the receptor binding domain (RBD) of the viral S1 protein to its main receptor, angiotensin converting enzyme 2 (ACE2). The RBD was fused to b...

Descripción completa

Detalles Bibliográficos
Autores principales: Lima, Marcelo A., Skidmore, Mark, Khanim, Farhat, Richardson, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670917/
https://www.ncbi.nlm.nih.gov/pubmed/33239166
http://dx.doi.org/10.1016/j.bbrc.2020.11.055

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670917/
https://www.ncbi.nlm.nih.gov/pubmed/33239166
http://dx.doi.org/10.1016/j.bbrc.2020.11.055

Ejemplares similares