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Development of a nano-luciferase based assay to measure the binding of SARS-CoV-2 spike receptor binding domain to ACE-2
To identify drugs that could potentially be used to treat infection with SARS-CoV-2, a high throughput 384-well assay was developed to measure the binding of the receptor binding domain (RBD) of the viral S1 protein to its main receptor, angiotensin converting enzyme 2 (ACE2). The RBD was fused to b...
Autores principales: | Lima, Marcelo A., Skidmore, Mark, Khanim, Farhat, Richardson, Alan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670917/ https://www.ncbi.nlm.nih.gov/pubmed/33239166 http://dx.doi.org/10.1016/j.bbrc.2020.11.055 |
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