Are redox changes a critical switch for mitotic progression?

Cell-cycle dependent redox changes result in increased protein oxidation in mitotic cells. We show that oxidative modifications of a conserved cysteine residue within Aurora A kinase (AURKA) can promote its activation during mitosis. Targeting redox-sensitive cysteine residues within AURKA may lead...

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Detalles Bibliográficos
Autores principales: Lim, Daniel C., Joukov, Vladimir, Yaffe, Michael B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670999/
https://www.ncbi.nlm.nih.gov/pubmed/33235921
http://dx.doi.org/10.1080/23723556.2020.1832419
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author Lim, Daniel C.
Joukov, Vladimir
Yaffe, Michael B.
author_facet Lim, Daniel C.
Joukov, Vladimir
Yaffe, Michael B.
author_sort Lim, Daniel C.
collection PubMed
description Cell-cycle dependent redox changes result in increased protein oxidation in mitotic cells. We show that oxidative modifications of a conserved cysteine residue within Aurora A kinase (AURKA) can promote its activation during mitosis. Targeting redox-sensitive cysteine residues within AURKA may lead to the development of novel anti-cancer agents with improved clinical efficacy.
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spelling pubmed-76709992020-11-23 Are redox changes a critical switch for mitotic progression? Lim, Daniel C. Joukov, Vladimir Yaffe, Michael B. Mol Cell Oncol Author’s Views Cell-cycle dependent redox changes result in increased protein oxidation in mitotic cells. We show that oxidative modifications of a conserved cysteine residue within Aurora A kinase (AURKA) can promote its activation during mitosis. Targeting redox-sensitive cysteine residues within AURKA may lead to the development of novel anti-cancer agents with improved clinical efficacy. Taylor & Francis 2020-10-23 /pmc/articles/PMC7670999/ /pubmed/33235921 http://dx.doi.org/10.1080/23723556.2020.1832419 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
Lim, Daniel C.
Joukov, Vladimir
Yaffe, Michael B.
Are redox changes a critical switch for mitotic progression?
title Are redox changes a critical switch for mitotic progression?
title_full Are redox changes a critical switch for mitotic progression?
title_fullStr Are redox changes a critical switch for mitotic progression?
title_full_unstemmed Are redox changes a critical switch for mitotic progression?
title_short Are redox changes a critical switch for mitotic progression?
title_sort are redox changes a critical switch for mitotic progression?
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670999/
https://www.ncbi.nlm.nih.gov/pubmed/33235921
http://dx.doi.org/10.1080/23723556.2020.1832419
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