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Are redox changes a critical switch for mitotic progression?

Cell-cycle dependent redox changes result in increased protein oxidation in mitotic cells. We show that oxidative modifications of a conserved cysteine residue within Aurora A kinase (AURKA) can promote its activation during mitosis. Targeting redox-sensitive cysteine residues within AURKA may lead...

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Detalles Bibliográficos
Autores principales:	Lim, Daniel C., Joukov, Vladimir, Yaffe, Michael B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2020
Materias:	Author’s Views
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670999/ https://www.ncbi.nlm.nih.gov/pubmed/33235921 http://dx.doi.org/10.1080/23723556.2020.1832419

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