Epigenetic suppression of FBXL7 promotes metastasis

Epigenetic reprogramming is emerging as a key mechanism for metastasis development. Our study identified a novel regulatory mechanism whereby promoter methylation-mediated epigenetic silencing of the gene encoding the ubiquitin ligase subunit F-box/LRR-repeat protein 7 (FBXL7) induces accumulation o...

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Detalles Bibliográficos
Autores principales: Moro, Loredana, Pagano, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671034/
https://www.ncbi.nlm.nih.gov/pubmed/33235922
http://dx.doi.org/10.1080/23723556.2020.1833698
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author Moro, Loredana
Pagano, Michele
author_facet Moro, Loredana
Pagano, Michele
author_sort Moro, Loredana
collection PubMed
description Epigenetic reprogramming is emerging as a key mechanism for metastasis development. Our study identified a novel regulatory mechanism whereby promoter methylation-mediated epigenetic silencing of the gene encoding the ubiquitin ligase subunit F-box/LRR-repeat protein 7 (FBXL7) induces accumulation of active c-SRC, which, in turn, activates epithelial-to-mesenchymal transition and supports cancer cell invasion and metastasis.
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spelling pubmed-76710342020-11-23 Epigenetic suppression of FBXL7 promotes metastasis Moro, Loredana Pagano, Michele Mol Cell Oncol Author’s Views Epigenetic reprogramming is emerging as a key mechanism for metastasis development. Our study identified a novel regulatory mechanism whereby promoter methylation-mediated epigenetic silencing of the gene encoding the ubiquitin ligase subunit F-box/LRR-repeat protein 7 (FBXL7) induces accumulation of active c-SRC, which, in turn, activates epithelial-to-mesenchymal transition and supports cancer cell invasion and metastasis. Taylor & Francis 2020-10-22 /pmc/articles/PMC7671034/ /pubmed/33235922 http://dx.doi.org/10.1080/23723556.2020.1833698 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
Moro, Loredana
Pagano, Michele
Epigenetic suppression of FBXL7 promotes metastasis
title Epigenetic suppression of FBXL7 promotes metastasis
title_full Epigenetic suppression of FBXL7 promotes metastasis
title_fullStr Epigenetic suppression of FBXL7 promotes metastasis
title_full_unstemmed Epigenetic suppression of FBXL7 promotes metastasis
title_short Epigenetic suppression of FBXL7 promotes metastasis
title_sort epigenetic suppression of fbxl7 promotes metastasis
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671034/
https://www.ncbi.nlm.nih.gov/pubmed/33235922
http://dx.doi.org/10.1080/23723556.2020.1833698
work_keys_str_mv AT moroloredana epigeneticsuppressionoffbxl7promotesmetastasis
AT paganomichele epigeneticsuppressionoffbxl7promotesmetastasis

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