Hiding in plain sight: structure and sequence analysis reveals the importance of the antibody DE loop for antibody-antigen binding

Antibody variable domains contain “complementarity-determining regions” (CDRs), the loops that form the antigen binding site. CDRs1-3 are recognized as the canonical CDRs. However, a fourth loop sits adjacent to CDR1 and CDR2 and joins the D and E strands on the antibody v-type fold. This “DE loop”...

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Detalles Bibliográficos
Autores principales: Kelow, Simon P., Adolf-Bryfogle, Jared, Dunbrack, Roland L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671036/
https://www.ncbi.nlm.nih.gov/pubmed/33180672
http://dx.doi.org/10.1080/19420862.2020.1840005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671036/
https://www.ncbi.nlm.nih.gov/pubmed/33180672
http://dx.doi.org/10.1080/19420862.2020.1840005

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