Impact of Fc N-linked glycans on in vivo clearance of an immunoglobulin G1 antibody produced by NS0 cell line

The heterogeneity of glycosylation on therapeutic monoclonal antibodies (mAbs) may affect the safety and efficacy of these agents. In particular, glycans of nonhuman origin, such as galactose-alpha-1,3-galactose (gal-α-gal) and N-glycolylneuraminic acid (NGNA), in the Fc region of therapeutic mAbs p...

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Detalles Bibliográficos
Autores principales: Kim, Jun, Luo, Haibin, White, Wendy, Rees, William, Venkat, Raghavan, Albarghouthi, Methal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671047/
https://www.ncbi.nlm.nih.gov/pubmed/33171078
http://dx.doi.org/10.1080/19420862.2020.1844928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671047/
https://www.ncbi.nlm.nih.gov/pubmed/33171078
http://dx.doi.org/10.1080/19420862.2020.1844928

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