Targeting copper metabolism to defeat KRAS-driven colorectal cancer

KRAS-driven cancers acquire profound metabolic dependencies that are intimately linked to tumor growth. Our work revealed that colorectal cancers that harbor KRAS mutations are addicted to copper metabolism. This adaptation renders tumor cells critically dependent on the copper transporter ATP7A, wh...

Descripción completa

Detalles Bibliográficos
Autores principales: Aubert, Léo, Nandagopal, Neethi, Roux, Philippe P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671051/
https://www.ncbi.nlm.nih.gov/pubmed/33235918
http://dx.doi.org/10.1080/23723556.2020.1822123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671051/
https://www.ncbi.nlm.nih.gov/pubmed/33235918
http://dx.doi.org/10.1080/23723556.2020.1822123

Ejemplares similares