Targeting copper metabolism to defeat KRAS-driven colorectal cancer

KRAS-driven cancers acquire profound metabolic dependencies that are intimately linked to tumor growth. Our work revealed that colorectal cancers that harbor KRAS mutations are addicted to copper metabolism. This adaptation renders tumor cells critically dependent on the copper transporter ATP7A, wh...

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Detalles Bibliográficos
Autores principales: Aubert, Léo, Nandagopal, Neethi, Roux, Philippe P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671051/
https://www.ncbi.nlm.nih.gov/pubmed/33235918
http://dx.doi.org/10.1080/23723556.2020.1822123
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author Aubert, Léo
Nandagopal, Neethi
Roux, Philippe P.
author_facet Aubert, Léo
Nandagopal, Neethi
Roux, Philippe P.
author_sort Aubert, Léo
collection PubMed
description KRAS-driven cancers acquire profound metabolic dependencies that are intimately linked to tumor growth. Our work revealed that colorectal cancers that harbor KRAS mutations are addicted to copper metabolism. This adaptation renders tumor cells critically dependent on the copper transporter ATP7A, which reveals copper metabolism as a promising therapeutic target for KRAS-driven colorectal cancers.
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spelling pubmed-76710512020-11-23 Targeting copper metabolism to defeat KRAS-driven colorectal cancer Aubert, Léo Nandagopal, Neethi Roux, Philippe P. Mol Cell Oncol Author’s Views KRAS-driven cancers acquire profound metabolic dependencies that are intimately linked to tumor growth. Our work revealed that colorectal cancers that harbor KRAS mutations are addicted to copper metabolism. This adaptation renders tumor cells critically dependent on the copper transporter ATP7A, which reveals copper metabolism as a promising therapeutic target for KRAS-driven colorectal cancers. Taylor & Francis 2020-10-07 /pmc/articles/PMC7671051/ /pubmed/33235918 http://dx.doi.org/10.1080/23723556.2020.1822123 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
Aubert, Léo
Nandagopal, Neethi
Roux, Philippe P.
Targeting copper metabolism to defeat KRAS-driven colorectal cancer
title Targeting copper metabolism to defeat KRAS-driven colorectal cancer
title_full Targeting copper metabolism to defeat KRAS-driven colorectal cancer
title_fullStr Targeting copper metabolism to defeat KRAS-driven colorectal cancer
title_full_unstemmed Targeting copper metabolism to defeat KRAS-driven colorectal cancer
title_short Targeting copper metabolism to defeat KRAS-driven colorectal cancer
title_sort targeting copper metabolism to defeat kras-driven colorectal cancer
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671051/
https://www.ncbi.nlm.nih.gov/pubmed/33235918
http://dx.doi.org/10.1080/23723556.2020.1822123
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