Cytoplasmic MYC is an anti-necroptotic protein

Cancer cells are often resistant to necroptosis as well as apotosis, but the underlying mechanisms are not fully understood. We recently revealed an important crosstalk between MYC, a potent oncogene, and receptor-interacting protein kinase 3 (RIPK3), a pivotal factor in inducing necroptosis. Mechan...

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Detalles Bibliográficos
Autores principales: Lee, Eun-Woo, Seong, Daehyeon, Song, Jaewhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671064/
https://www.ncbi.nlm.nih.gov/pubmed/33235915
http://dx.doi.org/10.1080/23723556.2020.1817697
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author Lee, Eun-Woo
Seong, Daehyeon
Song, Jaewhan
author_facet Lee, Eun-Woo
Seong, Daehyeon
Song, Jaewhan
author_sort Lee, Eun-Woo
collection PubMed
description Cancer cells are often resistant to necroptosis as well as apotosis, but the underlying mechanisms are not fully understood. We recently revealed an important crosstalk between MYC, a potent oncogene, and receptor-interacting protein kinase 3 (RIPK3), a pivotal factor in inducing necroptosis. Mechanistically, cytoplasmic MYC directly binds to RIPK3, inhibiting initial necrosome complex formation.
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spelling pubmed-76710642020-11-23 Cytoplasmic MYC is an anti-necroptotic protein Lee, Eun-Woo Seong, Daehyeon Song, Jaewhan Mol Cell Oncol Author’s Views Cancer cells are often resistant to necroptosis as well as apotosis, but the underlying mechanisms are not fully understood. We recently revealed an important crosstalk between MYC, a potent oncogene, and receptor-interacting protein kinase 3 (RIPK3), a pivotal factor in inducing necroptosis. Mechanistically, cytoplasmic MYC directly binds to RIPK3, inhibiting initial necrosome complex formation. Taylor & Francis 2020-10-12 /pmc/articles/PMC7671064/ /pubmed/33235915 http://dx.doi.org/10.1080/23723556.2020.1817697 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
Lee, Eun-Woo
Seong, Daehyeon
Song, Jaewhan
Cytoplasmic MYC is an anti-necroptotic protein
title Cytoplasmic MYC is an anti-necroptotic protein
title_full Cytoplasmic MYC is an anti-necroptotic protein
title_fullStr Cytoplasmic MYC is an anti-necroptotic protein
title_full_unstemmed Cytoplasmic MYC is an anti-necroptotic protein
title_short Cytoplasmic MYC is an anti-necroptotic protein
title_sort cytoplasmic myc is an anti-necroptotic protein
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671064/
https://www.ncbi.nlm.nih.gov/pubmed/33235915
http://dx.doi.org/10.1080/23723556.2020.1817697
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