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Probing the Dynamic Structure–Function and Structure-Free Energy Relationships of the Coronavirus Main Protease with Biodynamics Theory
[Image: see text] The SARS-CoV-2 main protease (M(pro)) is of major interest as an antiviral drug target. Structure-based virtual screening efforts, fueled by a growing list of apo and inhibitor-bound SARS-CoV/CoV-2 M(pro) crystal structures, are underway in many laboratories. However, little is kno...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671103/ https://www.ncbi.nlm.nih.gov/pubmed/33330838 http://dx.doi.org/10.1021/acsptsci.0c00089 |