Losses of human disease-associated genes in placental mammals

We systematically investigate whether losses of human disease-associated genes occurred in other mammals during evolution. We first show that genes lost in any of 62 non-human mammals generally have a lower degree of pleiotropy, and are highly depleted in essential and disease-associated genes. Desp...

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Detalles Bibliográficos
Autores principales: Sharma, Virag, Hiller, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Standard Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671337/
https://www.ncbi.nlm.nih.gov/pubmed/33575564
http://dx.doi.org/10.1093/nargab/lqz012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671337/
https://www.ncbi.nlm.nih.gov/pubmed/33575564
http://dx.doi.org/10.1093/nargab/lqz012

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