MR-LDP: a two-sample Mendelian randomization for GWAS summary statistics accounting for linkage disequilibrium and horizontal pleiotropy

The proliferation of genome-wide association studies (GWAS) has prompted the use of two-sample Mendelian randomization (MR) with genetic variants as instrumental variables (IVs) for drawing reliable causal relationships between health risk factors and disease outcomes. However, the unique features o...

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Detalles Bibliográficos
Autores principales: Cheng, Qing, Yang, Yi, Shi, Xingjie, Yeung, Kar-Fu, Yang, Can, Peng, Heng, Liu, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Methods Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671398/
https://www.ncbi.nlm.nih.gov/pubmed/33575584
http://dx.doi.org/10.1093/nargab/lqaa028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671398/
https://www.ncbi.nlm.nih.gov/pubmed/33575584
http://dx.doi.org/10.1093/nargab/lqaa028

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