Poly(A)-DG: A deep-learning-based domain generalization method to identify cross-species Poly(A) signal without prior knowledge from target species

In eukaryotes, polyadenylation (poly(A)) is an essential process during mRNA maturation. Identifying the cis-determinants of poly(A) signal (PAS) on the DNA sequence is the key to understand the mechanism of translation regulation and mRNA metabolism. Although machine learning methods were widely us...

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Detalles Bibliográficos
Autores principales: Zheng, Yumin, Wang, Haohan, Zhang, Yang, Gao, Xin, Xing, Eric P., Xu, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671507/
https://www.ncbi.nlm.nih.gov/pubmed/33151940
http://dx.doi.org/10.1371/journal.pcbi.1008297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671507/
https://www.ncbi.nlm.nih.gov/pubmed/33151940
http://dx.doi.org/10.1371/journal.pcbi.1008297

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