Oxidative stress antagonizes fluoroquinolone drug sensitivity via the SoxR-SUF Fe-S cluster homeostatic axis

The level of antibiotic resistance exhibited by bacteria can vary as a function of environmental conditions. Here, we report that phenazine-methosulfate (PMS), a redox-cycling compound (RCC) enhances resistance to fluoroquinolone (FQ) norfloxacin. Genetic analysis showed that E. coli adapts to PMS s...

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Detalles Bibliográficos
Autores principales: Gerstel, Audrey, Zamarreño Beas, Jordi, Duverger, Yohann, Bouveret, Emmanuelle, Barras, Frédéric, Py, Béatrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671543/
https://www.ncbi.nlm.nih.gov/pubmed/33137124
http://dx.doi.org/10.1371/journal.pgen.1009198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671543/
https://www.ncbi.nlm.nih.gov/pubmed/33137124
http://dx.doi.org/10.1371/journal.pgen.1009198

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